Abstract：Six Sigma is a statistical measure of variability, typically in a given process, and a business performance target specifically focused on critical customer specifications. It can help corporations to make the greatest achievements by quantifiably solving problems and optimize critical processes. Having to face up to the global drastic competition, Chinese enterprises must improve the quality of their product or service radically. On the other hand, the cost must level off. As committed management methodologies, Six Sigma should be adapted and applied by domestic enterprises to realize drastically improved business performance and bottom-line profitability.However, because of the special environment there are quite a few problems during the execution. Learning about what the organizations who are engaged in Six Sigma meet, four main problems are summarized, which are weak conscious, indifferent attitude of senior leaders, unfitted using of theory in execution and impatience. Furthermore, countermeasures are brought forward according to the problems above, so as to do some favorable work for the domestic corporations.